abstract：:Fifty-seven (35.6%) of 160 patients with papillary thyroid carcinoma had lymph node metastases at the primary treatment. Children and adolescents were most frequently affected (69.2%), followed by the age group of 21-40-year olds (38.8%). Those older than 40 had the lowest incidence of lymph node metastases (29.6%; p ...

journal_title：Journal of endocrinological investigation

authors： Ahuja S,Ernst H,Lenz K

更新日期：1991-07-01 00:00:00

abstract：:The authors report the results of a correlation study between the direct Immunobead Test (d-IBT) and other techniques for antisperm antibodies detection. The Gelatin Agglutination Test (GAT) and Tray Agglutination Test (TAT) were used to detect antibodies in blood serum and seminal plasma ("indirect methods"). The Dir...

journal_title：Journal of endocrinological investigation

authors： Dondero F,Lenzi A,Gandini L,Lombardo F,Culasso F

更新日期：1991-06-01 00:00:00

abstract：:The coexistence of hyperparathyroidism complicating thyrotoxicosis is quite rare. We report the case of one patient who presented with thyrotoxicosis, (total thyroxine of 15.1 micrograms/dl (5-13), free thyroxine index of 18 (4-15) and triiodothyronine by RIA of 305 ng/dl (70-230) and asymptomatic hypercalcemia of 15 ...

journal_title：Journal of endocrinological investigation

authors： McGowan DM,Vaswani A,Shperling I

更新日期：1991-04-01 00:00:00

abstract：:It has been shown that human calcitonin (hCT) is absorbed through the nasal mucosa when administered together with promoters like sodium glycocholate (SGC) or dihydrofusinate. The aim of this study was to compare the clinical and metabolic effect of intranasal (in) and intramuscular (im) hCT in patients with osteoporo...

journal_title：Journal of endocrinological investigation

authors： Pontiroli AE,Pajetta E,Calderara A,Alberetto M,Pozza G,Manganelli V,Resmini G,Tessari L,Maresca V

更新日期：1991-01-01 00:00:00

abstract：:Evaluation of thyroid status by measurement of free thyroid hormone concentrations seems particularly helpful in conditions with altered serum binding proteins. In pregnancy, a condition of increased thyroxine binding globulin, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations have been reporte...

journal_title：Journal of endocrinological investigation

authors： Roti E,Gardini E,Minelli R,Bianconi L,Flisi M

更新日期：1991-01-01 00:00:00

abstract：:A technique has been developed with which it has been possible to quantify the output of a wide variety of agonists including catecholamines, glucocorticoids, mineralocorticoids, enkephalins and various peptides, from the adrenal gland in the conscious unrestrained calf; also to investigate responses to electrical sti...

journal_title：Journal of endocrinological investigation

authors： Edwards AV,Ghatei MA,Bloom SR

更新日期：1990-12-01 00:00:00

abstract：:A dialyzable, thermostable inhibitor of normal thyroid peroxidase (TPO), with UV absorption maximum at 250-260 nm, was found in the digitonized, washed particulate fraction of two dyshormonogenetic goiters. No intrinsic TPO iodide-oxidation activity was detectable in either of these goiters, and their TPO iodination a...

journal_title：Journal of endocrinological investigation

authors： Rosenthal D,Carvalho-Guimarães DP,Knobel M,Medeiros-Neto GA

更新日期：1990-12-01 00:00:00

abstract：:We treated a 10 6/12 year old prepubertal male with hypophosphatemic rickets, who was growing poorly despite appropriate treatment with calcitriol and phosphate, with exogenous growth hormone (for an initial trial period of 4 months, followed by 14 months of continuous treatment at a dose of 4 IU three times weekly) e...

journal_title：Journal of endocrinological investigation

authors： Lanes R,Harrison HE

更新日期：1990-11-01 00:00:00

abstract：:A 52-year-old male presented himself with tachycardia crises which appeared first during childhood, increased in frequency without goiter or exophthalmos. Cardiac and adrenergic diseases were excluded. The thyroid function was normal regarding T4, free T4 and T3, TBG, radioiodine uptake, TSH and T3 suppressibility; ho...

journal_title：Journal of endocrinological investigation

authors： Jaffiol C,Baldet L,Torresani J,Bismuth J,Papachristou C

更新日期：1990-11-01 00:00:00

abstract：:Human gonadotropins are widely used for induction of ovulation in the treatment of anovulatory infertility and for induction of multiple follicular development (MFD) in in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and artificial insemination with husband's semen (AIH) programs. Reported is a pa...

journal_title：Journal of endocrinological investigation

authors： Mais V,Melis GB,Antinori D,Paoletti AM,Strigini F,Guerriero S,de Ruggiero A,Fioretti P

更新日期：1990-10-01 00:00:00

abstract：:In six patients suffering from amyotrophic lateral sclerosis we evaluated changes of T4, T3, TSH, PRL, and GH during treatment by continuous iv infusion of TRH for at least 15 days. No clinical improvement was detected. A significant rise of thyroid hormone levels was observed, as well as an upward trend of basal TSH ...

journal_title：Journal of endocrinological investigation

authors： Chiodini PG,Attanasio R,Liuzzi A,Cozzi R,Orlandi P,De Palo C,Dallabonzana D,Girotti F,Testa D

更新日期：1990-09-01 00:00:00

abstract：:Pyoderma gangrenosum is a rare chronic and recurrent skin disease characterized by progressing lesions from papulopustules to large necrotic sterile ulcers. Its definite etiology remains unknown. In a 40-year-old woman with typical pyoderma gangrenosum an intrasellar mass with suprasellar extension was diagnosed and r...

journal_title：Journal of endocrinological investigation

authors： Chanson P,Timsit J,Kujas M,Violante A,Guillausseau PJ,Derome PJ,Warnet A,Lubetzki J

更新日期：1990-09-01 00:00:00

abstract：:The adrenomedullary response to stimuli is often elevated in poorly controlled insulin dependent diabetic patients, and it is controversial whether the adrenomedullary hyperactivity induces the suppression of the circadian rhythm of catecholamines. We have studied the urinary excretion of catecholamines in 11 diabetic...

journal_title：Journal of endocrinological investigation

authors： Del Rio G,Carani C,Baldini A,Marrama P,Della Casa L

更新日期：1990-07-01 00:00:00

abstract：:The outcome of radioiodine therapy of Graves' hyperthyroidism was retrospectively evaluated in 274 consecutive patients treated from 1975 to 1984. At 1-yr follow-up, permanent hypothyroidism occurred in 36.9% of patients and the cumulative incidence of hypothyroidism progressively increased up to 79.3% after 7-10 yr. ...

journal_title：Journal of endocrinological investigation

authors： Marcocci C,Gianchecchi D,Masini I,Golia F,Ceccarelli C,Bracci E,Fenzi GF,Pinchera A

更新日期：1990-06-01 00:00:00

abstract：:It has been shown that the antithyroid drug methimazole (MMI) may affect B cells and possibly accessory cell function. In the present study we investigated in detail the effects of MMI on T cell in vitro proliferation. The following variables were evaluated: T cell proliferation following stimulation with phytohemaggl...

journal_title：Journal of endocrinological investigation

authors： Bagnasco M,Venuti D,Ciprandi G,Pesce G,Paolieri F,Canonica GW

更新日期：1990-06-01 00:00:00

abstract：:Osteocalcin (OC) concentration, a specific index of bone formation, was measured in 29 female patients with microprolactinoma (serum prolactin, PRL: 105 +/- 10.9 ng/ml; mean +/- SE). Mean OC levels were significantly lower than in controls (1.7 +/- 0.2 vs 5.1 +/- 0.3 ng/ml; p less than 0.001), being below the normal r...

journal_title：Journal of endocrinological investigation

authors： Sartorio A,Conti A,Ambrosi B,Muratori M,Morabito F,Faglia G

更新日期：1990-05-01 00:00:00

abstract：:The diagnosis of growth hormone (GH) deficiency (GHD) is currently based on failure to increase plasma GH levels to an arbitrary cutoff point of 7 or 10 micrograms/l in response to two provocative stimuli. False negative responses to these tests, however, frequently occur thus reducing their diagnostic reliability. Th...

journal_title：Journal of endocrinological investigation

authors： Ghigo E,Imperiale E,Boffano GM,Mazza E,Bellone J,Arvat E,Procopio M,Goffi S,Barreca A,Chiabotto P

更新日期：1990-04-01 00:00:00

abstract：:Brain beta-endorphin (beta-EP) plays an important role in regulating the hypothalamus-pituitary-gonadal axis activity. Cerebrospinal fluid (CSF) beta-EP levels seem to reflect the central rather than pituitary secretion. With the aim to correlate the changes of plasma estradiol (E2), progesterone, luteinizing hormone ...

journal_title：Journal of endocrinological investigation

authors： Nappi C,Petraglia F,Gambardella A,De Masellis G,Di Carlo C,Genazzani AR,Montemagno U

更新日期：1990-02-01 00:00:00

abstract：:We studied the possibility of an association between serum somatomedin-C (Sm-C) and thyroid hormone concentrations. For this purpose 34 hyperthyroid patients, 39 patients with primary hypothyroidism, 36 patients with severe nonthyroidal illnesses (NTI), and 63 euthyroid healthy control subjects were examined. The mean...

journal_title：Journal of endocrinological investigation

authors： Välimäki M,Liewendahl,Karonen SL,Helenius T,Suikkari AM

更新日期：1990-02-01 00:00:00

abstract：:Several in vivo experimental and clinical studies suggest that the production of thymic hormones, such as thymulin (Zn-FTS), is modulated by thyroid hormones. It was not determined in these studies, however whether such modulation is exerted directly on the thymic epithelial cells which synthesize and secrete thymic h...

journal_title：Journal of endocrinological investigation

authors： Mocchegiani E,Amadio L,Fabris N

更新日期：1990-02-01 00:00:00

abstract：:The long-acting somatostatin analogue SMS 201-995 has been used efficaciously in the therapy of metastatic carcinoid tumor, vasoactive intestinal peptide producing islet cell carcinoma, acromegaly, and TSH secreting pituitary tumors. We report the development of a gallstone in a patient treated for 23 months with a lo...

journal_title：Journal of endocrinological investigation

authors： Roti E,Minelli R,Gardini E,Salvi M,Bianconi L,Balducci L,Manfredi A,Braverman LE

更新日期：1990-01-01 00:00:00

abstract：:The in vivo suppressive effect of glucose and insulin on plasma free fatty acid concentrations was investigated in obese subjects with (n = 6) and without (n = 6) Type 2 (non-insulin-dependent) diabetes mellitus during a 4h-hyperglycemic glucose clamp (about 11.2 mmol/l). Somatostatin was infused (250 micrograms/h) du...

journal_title：Journal of endocrinological investigation

authors： Zancanaro C,Cigolini M,Bonora E,Moghetti P,Querena M,Muggeo M

更新日期：1990-01-01 00:00:00

abstract：:N-Terminal (1-76) portion of proopiomelanocortin (hNT) was measured in normals, Addison's, Nelson's, Cushing's disease, and in dexamethasone suppressible hyperaldosteronism (DSH) by using a specific homologous RIA. Mean basal immunoreactive hNT level was 94.2 +/- 6 pg/ml (mean +/- SE) in normal subjects. In Cushing's ...

journal_title：Journal of endocrinological investigation

authors： Boscaro M,Giacomazzi P,Sonino N,Fallo F,Girard F,Bertagna X,Mantero F

更新日期：1990-01-01 00:00:00

abstract：:A patient with Graves' disease associated with severe muscle weakness who was finally diagnosed as polymyositis by pathological examination of the muscle is reported. A 28-year-old women was incidentally found to have hyperthyroidism when she consulted a hospital for the evaluation and treatment of anemia in 1979. She...

journal_title：Journal of endocrinological investigation

authors： Sakata S,Fuwa Y,Goshima E,Nakamura S,Yamakita N,Maeda M,Miura K

更新日期：1989-12-01 00:00:00

abstract：:Pathogenesis of idiopathic diabetes insipidus is unknown and the clinical course of the disease is permanent. However, we observed one patient who was diagnosed of idiopathic diabetes insipidus spontaneously reverted after approximately 13 months. The cause and pathogenesis of the disease were not evident. However, so...

journal_title：Journal of endocrinological investigation

authors： Ohshima K,Okada S,Onai T,Umahara M,Mori M,Kobayashi I,Kobayashi S,Katakai S

更新日期：1989-11-01 00:00:00

abstract：:Neurological disorders, such as seizures, are not infrequently associated with anti-leukemic therapy. It has been hypothesized that a disrupted peptidergic transmission between neurons could be the cellular basis of the neurological dysfunction. Since endogenous opioids have been recently found to alter neuronal funct...

journal_title：Journal of endocrinological investigation

authors： Iannetti P,Fabbri A,Meloni G,Moleti ML,Ulisse S,Mandelli F,Isidori A,Imperato C

更新日期：1989-10-01 00:00:00

abstract：:GH secretion in acromegaly was studied in 8 patients before and during treatment with SMS 201-995, a somatostatin analogue, 100 micrograms twice daily, by evaluating GH day profiles and GH suppressibility after oral glucose tolerance tests (OGTT). Normalization of GH secretion, estimated by OGTT, was only observed in ...

journal_title：Journal of endocrinological investigation

authors： van Liessum PA,Pieters GF,Smals AG,Swinkels LM,Benraad TJ,Kloppenborg PW

更新日期：1989-09-01 00:00:00

abstract：:Recent data seem to suggest that LHRH may be involved in the modulation of PRL secretion. We studied the PRL pattern in 9 males (age range 18-38 yr) with idiopathic hypogonadotropic hypogonadism (IHH) before and during long-term pulsatile LHRH therapy (120-160 ng/kg bw every 120 min sc) in order to evaluate variations...

journal_title：Journal of endocrinological investigation

authors： Giusti M,Traverso L,Cavagnaro P,Torre R,Durante R,Giordano G

更新日期：1989-09-01 00:00:00

abstract：:The assessment of growth hormone (GH) secretory status is often difficult because of the intermittent nature of GH release and resulting wide swings in plasma GH levels. Urinary GH excretion holds promise as an index of integrated plasma GH free of this limitation, but technical problems have prevented its use until r...

journal_title：Journal of endocrinological investigation

authors： Winer LM,Shaw MA,Baumann G

更新日期：1989-07-01 00:00:00

abstract：:The effects of growth hormone-releasing hormone (GHRH) were studied on densely granulated somatotroph adenoma cells and sparsely granulated somatotroph adenoma cells in culture by measuring release of growth hormone (GH) as well as ultrastructural morphometrical parameters and comparing them with those of control aden...

journal_title：Journal of endocrinological investigation

authors： Kawakita S,Asa SL,Kovacs K

更新日期：1989-07-01 00:00:00

abstract：:Carbenoxolone is a derivative of glycyrrhetinic acid used for the treatment of peptic ulcer and gastritis, with salt and water retention a very common side-effect. To investigate this drug-induced pseudohyperaldosteronism we have studied 6 male volunteers before, during and after treatment with carbenoxolone for 7 day...

journal_title：Journal of endocrinological investigation

authors： Armanini D,Scali M,Zennaro MC,Karbowiak I,Wallace C,Lewicka S,Vecsei P,Mantero F

更新日期：1989-05-01 00:00:00

abstract：:Thyroid function tests were evaluated in 34 patients with acute viral hepatitis (AVH) and in 38 healthy controls (C). As expected, AVH patients displayed a significant increase in T4, rT3 and TBG serum levels with respect to C, while FT4 and TSH concentrations were similar. A positive correlation between TBG and T4 wa...

journal_title：Journal of endocrinological investigation

authors： Pagliacci MC,Pelicci G,Francisci D,Giammartino C,Fedeli L,Stagni G,Nicoletti I

更新日期：1989-03-01 00:00:00

abstract：:The present study was designed to assess the transfer of thyroglobulin (Tg) and anti-Tg antibodies (TgAb) to saliva in subjects with positive TgAb in their sera. Group I consisted of normal euthyroid control subjects (n = 10). Group II were patients with various thyroid disorders and no TgAb in their sera (n = 6). Gro...

journal_title：Journal of endocrinological investigation

authors： Van Herle AJ,Rosenblit PD,Van Herle TL,Van Herle P,Greipel M,Kellett K

更新日期：1989-03-01 00:00:00

abstract：:Aromatase activity for androstenedione was measured in stromal cells of human uterine endometrium throughout the menstrual cycle. The effect of progestogen on aromatase activity was also examined in the endometrial stromal cells. Aromatase activity tended to be high in the proliferative cells compared to the secretory...

journal_title：Journal of endocrinological investigation

authors： Yamamoto T,Shiroshita K,Kitawaki J,Okada H

更新日期：1989-03-01 00:00:00

abstract：:A 33-year-old female presented in 1966 with striking pigmentation, typical of Addison's disease, and amenorrhea. Endocrine assessment then showed normal basal serum cortisol and urinary hydroxysteroid levels, but serum cortisol did not respond to stimulation with either exogenous ACTH or lysine vasopressin. Steroid re...

journal_title：Journal of endocrinological investigation

authors： Whitehead EM,Atkinson AB,Hadden DR,Weaver J,Sheridan B

更新日期：1989-03-01 00:00:00

abstract：:The regulation of GH secretion involves the harmonious integration of factors acting at the hypothalamic and pituitary levels summating to produce the peripheral patterns of intermittent GH secretion observed in man and experimental animals under physiologic and experimental conditions. SRIH and GHRH act primarily at ...

journal_title：Journal of endocrinological investigation

authors： Root AW

更新日期：1989-01-01 00:00:00

abstract：:Ketoacidosis is a metabolic alteration caused by absolute or relative insulin deficiency and oversecretion of glucagon. Prompt diagnosis and rapid initiation of treatment are mandatory to avoid the complications and fatal outcome. Reduction of plasma glucose to levels within acceptable limits, block of ketogenesis, re...

journal_title：Journal of endocrinological investigation

authors： Reitano G

更新日期：1989-01-01 00:00:00

abstract：:The effects of estriol on serum prolactin (PRL) and LH levels, on the pituitary response to TRH and LHRH and on the synthesis and release of PRL from the anterior pituitary gland were investigated in female rats. The increase of serum PRL levels after estradiol administration was found to be associated with an increas...

journal_title：Journal of endocrinological investigation

authors： Diaz MC,Seilicovich A,Duvilanski BH,Siseles N,Lasaga M,Debeljuk L

更新日期：1989-01-01 00:00:00

abstract：:Final height was evaluated in 47 patients with classical 21-hydroxylase treated since diagnosis, and in 29 patients with nonclassical (NC) 21-hydroxylase deficiency who had never been treated before reaching final adult height. Classical patients achieved final heights consistently below the mean for the general popul...

journal_title：Journal of endocrinological investigation

authors： New MI,Gertner JM,Speiser PW,Del Balzo P

更新日期：1989-01-01 00:00:00

abstract：:Cimetidine, an H2 receptor antagonist, is a potent stimulant of PRL secretion in normal women. In the present study, the PRL response to cimetidine was studied in 34 normal pregnant women and their fetuses during labor. Serum maternal PRL levels increased significantly after the acute iv injection of 400 mg cimetidine...

journal_title：Journal of endocrinological investigation

authors： Messinis IE,Tsirkas N,Diamantis K,Vasakos S,Tsolas O,Lolis D

更新日期：1988-12-01 00:00:00